Повышение артериальной жесткости у пациентов с субклинической формой болезни Бехчета на основании оценки каротидно-феморальной скорости распространения пульсовой волны

Актуальность Болезнь Бехчета (ББ) - это хроническое мультисистемное заболевание, характеризующееся поражением сосудов. Острые и хронические воспалительные процессы, связанные с ББ, могут вызвать эндотелиальную дисфункцию, которая затем может привести к последующему увеличению артериальной жесткости и изменению скорости распространения пульсовой волны (СПВ).
Цель Оценка измерений СПВ у пациентов с неактивной ББ и лиц из группы контроля.
Материалы и методы Было изучено 50 пациентов с неактивной ББ и 49 здоровых добровольцев без известных сердечно-сосудистых заболеваний. СПВ между сонной и бедренной артерией (каротидно-феморальная СПВ, кфСПВ) была определена у всех пациентов одним и тем же специалистом-исследователем с использованием прибора Complior (Colson, Paris, France).
Результаты Средняя продолжительность болезни составила 3,23±2,31 года. Пациенты с ББ (средний возраст 36,04±9,94 лет) имели значительно более высокие уровни кфСПВ по сравнению с контролем (9,57±1,88 против 8,47±1,13 м/с; p=0,003). Было установлено, что СПВ положительно коррелирует с возрастом, систолическим, диастолическим, средним артериальным давлением, обхватом талии и соотношением талия/бедра.
Выводы В настоящем исследовании продемонстрировано, что у пациентов с неактивной ББ по сравнению со здоровыми лицами значительно повышена артериальная жесткость, оцененная по увеличению кфСПВ.

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