Клиническая картина стрессорной кардиомиопатии (синдром такотсубо) и проблема дифференциальной диагностики с острым инфарктом миокарда
Аннотация
Представленные данные свидетельствуют, что синдром такотсубо (СТ) характеризуется отсутствием обструкции коронарных артерий, сократительной дисфункцией сердца, апикальным баллонированием, сердечной недостаточностью, у части пациентов – подъемом сегмента ST и удлинением интервала QTc. У каждого десятого пациента с СТ развиваются желудочковые аритмии. У большинства пациентов с СТ отмечается подъем уровня маркеров некроза (тропонин I, тропонин Т, креатинфосфокиназа-МВ (КФК-МВ)), который существенно меньше, чем у больных с острым инфарктом миокарда (ОИМ) с подъемом сегмента ST. Уровень N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP), напротив, существенно выше у больных с СТ, чем у пациентов с ОИМ. Дифференциальная диагностика СТ и ОИМ должна базироваться на комплексном подходе, заключающемся в использовании ангиографии коронарных сосудов, эхокардиографии, анализе ЭКГ, магнитно-резонансной томографии, однофотонной эмиссионной компьютерной томографии, определении уровня тропонинов, КФК-МВ, NT-proBNP.
Об авторах
Е. С. Прокудина
«Научно-исследовательский институт кардиологии», «Томский национальный исследовательский медицинский центр» Российской академии наук, Томск, Россия
Россия
к.м.н., н.с. лаборатории экспериментальной кардиологии
Россия
к.м.н., н.с. лаборатории экспериментальной кардиологии
Б. К. Курбатов
«Научно-исследовательский институт кардиологии», «Томский национальный исследовательский медицинский центр» Российской академии наук, Томск, Россия
Россия
Россия
аспирант. лаборатории экспериментальной кардиологии
Л. Н. Маслов
«Научно-исследовательский институт кардиологии», «Томский национальный исследовательский медицинский центр» Российской академии наук, Томск, Россия
Россия
д.м.н., профессор, руководитель лаборатории экспериментальной кардиологии
Россия
д.м.н., профессор, руководитель лаборатории экспериментальной кардиологии
Список литературы
1. Sato H, Tateishi H, Uchida T et al. Tako-Tsubo–like left ventricular dysfunction due to multivessel coronary spasm. 1990; [In: Kodama K, Haze K, Hori M, editors. Clinical aspect of myocardial injury: from ischemia to heart failure (in Japanese). Tokyo: Kagakuhyoronsha Publishing Co; 1990. p.56-64.]
2. Pavin D, Le Breton H, Daubert C. Human stress cardiomyopathy mimicking acute myocardial syndrome. Heart. 1997;78(5):509–11. DOI: 10.1136/hrt.78.5.509
3. Kuo BT, Choubey R, Novaro GM. Reduced estrogen in menopause may predispose women to takotsubo cardiomyopathy. Gender Medicine. 2010;7(1):71–7. DOI: 10.1016/j.genm.2010.01.006
4. Y-Hassan S, Tornvall P. Epidemiology, pathogenesis, and management of takotsubo syndrome. Clinical Autonomic Research. 2018;28(1):53–65. DOI: 10.1007/s10286-017-0465-z
5. Yerasi C, Koifman E, Weissman G, Wang Z, Torguson R, Gai J et al. Impact of triggering event in outcomes of stress-induced (Takotsubo) cardiomyopathy. European Heart Journal: Acute Cardiovascular Care. 2017;6(3):280–6. DOI: 10.1177/2048872616633881
6. Sobue Y, Watanabe E, Ichikawa T, Koshikawa M, Yamamoto M, Harada M et al. Physically triggered Takotsubo cardiomyopathy has a higher in-hospital mortality rate. International Journal of Cardiology. 2017;235:87–93. DOI: 10.1016/j.ijcard.2017.02.090
7. Scally C, Abbas H, Ahearn T, Srinivasan J, Mezincescu A, Rudd A et al. Myocardial and Systemic Inflammation in Acute Stress-Induced (Takotsubo) Cardiomyopathy. Circulation. 2019;139(13):1581–92. DOI: 10.1161/CIRCULATIONAHA.118.037975
8. Lemor A, Ramos‐Rodriguez AJ, De La Villa R, Hosseini Dehkordi SH, Vazquez de Lara F, Lee S et al. Impact of gender on in‐hospital outcomes in patients with Takotsubo syndrome: A nationwide analysis from 2006 to 2014. Clinical Cardiology. 2019;42(1):13–8. DOI: 10.1002/clc.23109
9. Kim H, Senecal C, Lewis B, Prasad A, Rajiv G, Lerman LO et al. Natural history and predictors of mortality of patients with Takotsubo syndrome. International Journal of Cardiology. 2018;267:22–7. DOI: 10.1016/j.ijcard.2018.04.139
10. Ueyama T, Kasamatsu K, Hano T, Tsuruo Y, Ishikura F. Catecholamines and Estrogen Are Involved in the Pathogenesis of Emotional Stress-induced Acute Heart Attack. Annals of the New York Academy of Sciences. 2008;1148(1):479–85. DOI: 10.1196/annals.1410.079
11. Feng Y, Madungwe NB, da Cruz Junho CV, Bopassa JC. Activation of G protein-coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia/reperfusion injury by reducing mitochondrial dysfunction and mitophagy. British Journal of Pharmacology. 2017;174(23):4329–44. DOI: 10.1111/bph.14033
12. Menazza S, Sun J, Appachi S, Chambliss KL, Kim SH, Aponte A et al. Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice. Journal of Molecular and Cellular Cardiology. 2017;107:41–51. DOI: 10.1016/j.yjmcc.2017.04.004
13. Sharkey SW, Windenburg DC, Lesser JR, Maron MS, Hauser RG, Lesser JN et al. Natural History and Expansive Clinical Profile of Stress (Tako-Tsubo) Cardiomyopathy. Journal of the American College of Cardiology. 2010;55(4):333–41. DOI: 10.1016/j.jacc.2009.08.057
14. Ghadri JR, Sarcon A, Diekmann J, Bataiosu DR, Cammann VL, Jurisic S et al. Happy heart syndrome: role of positive emotional stress in takotsubo syndrome. European Heart Journal. 2016;37(37):2823–9. DOI: 10.1093/eurheartj/ehv757
15. Chhabra L, Khalid N, Sareen P. Extremely Low Prevalence of Takotsubo Cardiomyopathy and Transient Cardiac Dysfunction in Stroke Patients With T-wave Abnormalities. The American Journal of Cardiology. 2019;123(6):1009. DOI: 10.1016/j.amjcard.2019.01.001
16. Dorfman T, Aqel R, Allred J, Woodham R, Iskandrian AE. Takotsubo Cardiomyopathy Induced by Treadmill Exercise Testing: An Insight Into the Pathophysiology of Transient Left Ventricular Apical (or Midventricular) Ballooning in the Absence of Obstructive Coronary Artery Disease. Journal of the American College of Cardiology. 2007;49(11):1223–5. DOI: 10.1016/j.jacc.2006.12.033
17. Skolnick AH. Transient Apical Ballooning Syndrome Precipitated by Dobutamine Stress Testing. Annals of Internal Medicine. 2009;150(7):501–2. DOI: 10.7326/0003-4819-150-7-200904070-00015
18. Narayanan A, Russell MD, Sundararaman S, Shankar KK, Artman B. Takotsubo cardiomyopathy following electroconvulsive therapy: an increasingly recognised phenomenon. Case Reports. 2014;2014(1):bcr2014206816. DOI: 10.1136/bcr-2014-206816
19. Vieira A, Batista B, Tribolet de Abreu T. Iatrogenic Takotsubo Cardiomyopathy Secondary to Norepinephrine by Continuous Infusion for Shock. European Journal of Case Reports in Internal Medicine. 2018;5(7):000894. DOI: 10.12890/2018_000894
20. Kido K, Guglin M. Drug-Induced Takotsubo Cardiomyopathy. Journal of Cardiovascular Pharmacology and Therapeutics. 2017;22(6):552–63. DOI: 10.1177/1074248417708618
21. Olson PC, Agarwal V, Lafferty JC, Bekheit S. Takotsubo Cardiomyopathy precipitated by opiate withdrawal. Heart & Lung. 2018;47(1):73–5. DOI: 10.1016/j.hrtlng.2017.10.001
22. Sarcon A, Ghadri J-R, Wong G, Luscher TF, Templin C, Amsterdam E. Takotsubo cardiomyopathy associated with opiate withdrawal. QJM. 2014;107(4):301–2. DOI: 10.1093/qjmed/hct219
23. Lemesle F, Lemesle F, Nicola W, Pierre Jonville-Béra A. First case of stress cardiomyopathy as a result of methadone withdrawal secondary to drug-drug interaction. The American Journal of Emergency Medicine. 2010;28(3):387.e5-387.e6. DOI: 10.1016/j.ajem.2009.07.007
24. Christensen TE, Bang LE, Holmvang L, Skovgaard DC, Oturai DB, Søholm H et al. 123I-MIBG Scintigraphy in the Subacute State of Takotsubo Cardiomyopathy. JACC: Cardiovascular Imaging. 2016;9(8):982–90. DOI: 10.1016/j.jcmg.2016.01.028
25. Marfella R, Barbieri M, Sardu C, Rizzo MR, Siniscalchi M, Paolisso P et al. Effects of α-lipoic acid therapy on sympathetic heart innervation in patients with previous experience of transient takotsubo cardiomyopathy. Journal of Cardiology. 2016;67(2):153–61. DOI: 10.1016/j.jjcc.2015.07.012
26. Smeijers L, Szabó BM, Kop WJ. Psychological distress and personality factors in takotsubo cardiomyopathy. Netherlands Heart Journal. 2016;24(9):530–7. DOI: 10.1007/s12471-016-0861-3
27. Núñez-Gil IJ, Bernardo E, Feltes G, Escaned J, Mejía-Rentería HD, De Agustín JA et al. Platelet function in Takotsubo cardiomyopathy. Journal of Thrombosis and Thrombolysis. 2015;39(4):452–8. DOI: 10.1007/s11239-014-1109-y
28. Uchida Y, Egami H, Uchida Y, Sakurai T, Kanai M, Shirai S et al. Possible Participation of Endothelial Cell Apoptosis of Coronary Microvessels in the Genesis of Takotsubo Cardiomyopathy. Clinical Cardiology. 2010;33(6):371–7. DOI: 10.1002/clc.20777
29. Vaccaro A, Despas F, Delmas C, Lairez O, Lambert E, Lambert G et al. Direct Evidences for Sympathetic Hyperactivity and Baroreflex Impairment in Tako Tsubo Cardiopathy. PLoS ONE. 2014;9(3):e93278. DOI: 10.1371/journal.pone.0093278
30. Lee SJ, Kang JG, Ryu OH, Kim CS, Ihm S-H, Choi MG et al. The relationship of thyroid hormone status with myocardial function in stress cardiomyopathy. European Journal of Endocrinology. 2009;160(5):799–806. DOI: 10.1530/EJE-08-0808
31. Nandal S, Castles A, Asrar ul Haq M, van Gaal W. Takotsubo cardiomyopathy triggered by status epilepticus: case report and literature review. BMJ Case Reports. 2019;12(1):e225924. DOI: 10.1136/bcr2018-225924
32. Belcour D, Jabot J, Grard B, Roussiaux A, Ferdynus C, Vandroux D et al. Prevalence and Risk Factors of Stress Cardiomyopathy After Convulsive Status Epilepticus in ICU Patients: Critical Care Medicine. 2015;43(10):2164–70. DOI: 10.1097/CCM.0000000000001191
33. Yamaguchi H, Nagase H, Yoshida S, Tokumoto S, Hayashi K, Toyoshima D et al. Acute encephalopathy with biphasic seizures and late reduced diffusion accompanied by Takotsubo cardiomyopathy. Brain and Development. 2019;41(3):305–9. DOI: 10.1016/j.braindev.2018.10.002
34. Finsterer J, Stollberger C. Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report. Journal of Medical Case Reports. 2019;13(1):22. DOI: 10.1186/s13256-018-1928-0
35. Binaghi G, Congia D, Cossa S, Ganga R, Giardina G, Matta G et al. Seizures and recurrence of Takotsubo syndrome: One clinical presentation and trigger, but two different anatomical variants in the same patient. A case to meditate on. Seizure. 2018;63:37–9. DOI: 10.1016/j.seizure.2018.10.014
36. Young RSK, Osbakken MD, Briggs RW, Yagel SK, Rice DW, Goldberg S. 31P NMR study of cerebral metabolism during prolonged seizures in the neonatal dog. Annals of Neurology. 1985;18(1):14–20. DOI: 10.1002/ana.410180104
37. Meierkord H, Shorvon S, Lightman SL. Plasma concentrations of prolactin, noradrenaline, vasopressin and oxytocin during and after a prolonged epileptic seizure. Acta Neurologica Scandinavica. 2009;90(2):73–7. DOI: 10.1111/j.1600-0404.1994.tb02682.x
38. Akashi YJ, Nef HM, Lyon AR. Epidemiology and pathophysiology of Takotsubo syndrome. Nature Reviews Cardiology. 2015;12(7):387–97. DOI: 10.1038/nrcardio.2015.39
39. Kato K, Lyon AR, Ghadri J-R, Templin C. Takotsubo syndrome: aetiology, presentation and treatment. Heart. 2017;103(18):1461–9. DOI: 10.1136/heartjnl-2016-309783
40. Heubach JF, Ravens U, Kaumann AJ. Epinephrine Activates Both Gs and Gi Pathways, but Norepinephrine Activates Only the Gs Pathway through Human β2-Adrenoceptors Overexpressed in Mouse Heart. Molecular Pharmacology. 2004;65(5):1313–22. DOI: 10.1124/ mol.65.5.1313
41. Heubach JF, Blaschke M, Harding SE, Ravens U, Kaumann AJ. Cardiostimulant and cardiodepressant effects through overexpressed human β2-adrenoceptors in murine heart: regional differences and functional role of β1-adrenoceptors. Naunyn-Schmiedeberg’s Archives of Pharmacology. 2003;367(4):380–90. DOI: 10.1007/s00210-002-0681-4
42. Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O’Gara P et al. High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β2-Adrenergic Receptor/Gi–Dependent Manner: A New Model of Takotsubo Cardiomyopathy. Circulation. 2012;126(6):697– 706. DOI: 10.1161/CIRCULATIONAHA.112.111591
43. Kuroda R, Shintani-Ishida K, Unuma K, Yoshida K. Immobilization Stress With α2-Adrenergic Stimulation Induces Regional and Transient Reduction of Cardiac Contraction Through Gi Coupling in Rats. International Heart Journal. 2015;56(5):537–43. DOI: 10.1536/ ihj.15-034
44. Shao Y, Redfors B, Scharin Täng M, Möllmann H, Troidl C, Szardien S et al. Novel rat model reveals important roles of β-adrenoreceptors in stress-induced cardiomyopathy. International Journal of Cardiology. 2013;168(3):1943–50. DOI: 10.1016/j.ijcard.2012.12.092
45. Sachdeva J, Dai W, Kloner RA. Functional and Histological Assessment of an Experimental Model of Takotsubo’s Cardiomyopathy. Journal of the American Heart Association. 2014;3(3):e000921. DOI: 10.1161/JAHA.114.000921
46. Communal C, Singh K, Pimentel DR, Colucci WS. Norepinephrine Stimulates Apoptosis in Adult Rat Ventricular Myocytes by Activation of the -Adrenergic Pathway. Circulation. 1998;98(13):1329–34. DOI: 10.1161/01.CIR.98.13.1329
47. Corley KC, Mauck HP, Shiel FO, Barber JH, Clark LS, Blocher CR. Myocardial Dysfunction and Pathology Associated with Environmental Stress in Squirrel Monkey: Effect of Vagotomy and Propranolol. Psychophysiology. 1979;16(6):554–60. DOI: 10.1111/j.1469-8986.1979.tb01520.x
48. Häggendal J, Johansson G, Jönsson L, Thorén-Tolling K. Effect of Propranolol on Myocardial Cell Necroses and Blood Levels of Catecholamines in Pigs Subjected to Stress. Acta Pharmacologica et Toxicologica. 2009;50(1):58–66. DOI: 10.1111/j.1600-0773.1982.tb00940.x
49. Takano Y, Ueyama T, Ishikura F. Azelnidipine, unique calcium channel blocker could prevent stress-induced cardiac dysfunction like α·βblocker. Journal of Cardiology. 2012;60(1):18–22. DOI: 10.1016/j.jjcc.2012.01.017
50. Ishikura F, Takano Y, Ueyama T. Acute effects of beta-blocker with intrinsic sympathomimetic activity on stress-induced cardiac dysfunction in rats. Journal of Cardiology. 2012;60(6):470–4. DOI: 10.1016/j.jjcc.2012.07.004
51. Sisson JC, Wieland DM, Sherman P, Mangner TJ, Tobes MC, Jacques S. Metaiodobenzylguanidine as an index of the adrenergic nervous system integrity and function. Journal of Nuclear Medicine. 1987;28(10):1620–4. PMID: 3655914
52. DeGrado TR, Zalutsky MR, Vaidyanathan G. Uptake mechanisms of meta-[123I]iodobenzylguanidine in isolated rat heart. Nuclear Medicine and Biology. 1995;22(1):1–12. DOI: 10.1016/0969-8051(94)00084-W
53. Glowniak JV, Kilty JE, Amara SG, Hoffman BJ, Turner FE. Evaluation of metaiodobenzylguanidine uptake by the norepinephrine, dopamine and serotonin transporters. Journal of Nuclear Medicine. 1993;34(7):1140–6. PMID: 8315492
54. Guilloteau D, Chalon S, Baulieu JL, Huguet F, Desplanches G, Chambon C et al. Comparison of MIBG and monoamines uptake mechanisms: Pharmacological animal and blood platelets studies. European Journal of Nuclear Medicine. 1988;14–14(7–8):341–344. DOI: 10.1007/BF00254380
55. Morel O, Sauer F, Imperiale A, Cimarelli S, Blondet C, Jesel L et al. Importance of Inflammation and Neurohumoral Activation in Takotsubo Cardiomyopathy. Journal of Cardiac Failure. 2009;15(3):206–13. DOI: 10.1016/j.cardfail.2008.10.031
56. Humbert O, Stamboul K, Gudjoncik A, Kanoun S, Richard C, Cochet A et al. Dual Diagnostic Role of 123I-MIBG Scintigraphy in Inverted-Takotsubo Pattern Cardiomyopathy: Clinical Nuclear Medicine. 2015;40(10):816–8. DOI: 10.1097/RLU.0000000000000864
57. Sestini S, Pestelli F, Leoncini M, Bellandi F, Mazzeo C, Mansi L et al. The natural history of takotsubo syndrome: a two-year follow-up study with myocardial sympathetic and perfusion G-SPECT imaging. European Journal of Nuclear Medicine and Molecular Imaging. 2017;44(2):267–83. DOI: 10.1007/s00259-016-3575-2
58. Burgdorf C, Hof K von, Schunkert H, Kurowski V. Regional alterations in myocardial sympathetic innervation in patients with transient left-ventricular apical ballooning (Tako-Tsubo cardiomyopathy). Journal of Nuclear Cardiology. 2008;15(1):65–72. DOI: 10.1016/j.nuclcard.2007.08.005
59. Tan AY, Verrier RL. The role of the autonomic nervous system in cardiac arrhythmias. P. 135-145. [DOI: 10.1016/B978-0-444-53491- 0.00012-2]. In: Handbook of Clinical Neurology. [ISBN: 978-0-444- 53491-0]. Elsevier;2013.
60. Donohue D, Ahsan C, Sanaei-Ardekani M, Movahed M-R. Early Diagnosis of Stress-Induced Apical Ballooning Syndrome Based on Classic Echocardiographic Findings and Correlation with Cardiac Catheterization. Journal of the American Society of Echocardiography. 2005;18(12):1423.e1-1423.e8. DOI: 10.1016/j.echo.2005.05.017
61. Kurisu S, Sato H, Kawagoe T, Ishihara M, Shimatani Y, Nishioka K et al. Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: A novel cardiac syndrome mimicking acute myocardial infarction. American Heart Journal. 2002;143(3):448–55. DOI: 10.1067/mhj.2002.120403
62. Kawai S, Kitabatake A, Tomoike H, Takotsubo Cardiomyopathy Study Grou. Guidelines for Diagnosis of Takotsubo (Ampulla) Cardiomyopathy. Circulation Journal. 2007;71(6):990–2. DOI: 10.1253/ circj.71.990
63. Stiermaier T, Möller C, Graf T, Eitel C, Desch S, Thiele H et al. Prognostic Usefulness of the Ballooning Pattern in Patients With Takotsubo Cardiomyopathy. The American Journal of Cardiology. 2016;118(11):1737–41. DOI: 10.1016/j.amjcard.2016.08.055
64. El-Battrawy I, Behnes M, Ansari U, Hillenbrand D, Haghi D, Hoffmann U et al. Comparison and outcome analysis of patients with apical and non-apical takotsubo cardiomyopathy. QJM. 2016;109(12):797–802. DOI: 10.1093/qjmed/hcw092
65. Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J et al. Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy. Frontiers in Cardiovascular Medicine. 2017;49(4):49. DOI: 10.3389/fcvm.2017.00049
66. Dias A, Franco E, Janzer S, Koshkelashvili N, Bhalla V, Pressman GS et al. Performance of a novel clinic score in differentiating Takotsubo cardiomyopathy from ST elevation myocardial infarction within the first 24h. International Journal of Cardiology. 2016;203:12–4. DOI: 10.1016/j.ijcard.2015.10.044
67. Sun T, Ming Z, Liu Z, Lennon RJ, Yang S-W, Kwon T-G et al. Prevalence of diastolic function and clinical impact on long-term outcome in takotsubo cardiomyopathy. International Journal of Cardiology. 2017;244:7–12. DOI: 10.1016/j.ijcard.2017.06.068
68. Pérez Benítez SE, Pastor Ramírez O, Salazar Bonilla CJ, Solera Marín J. Cardiogenic shock induced by Takotsubo cardiomyopathy in early postoperative adrenalectomy period. Revista Española de Anestesiología y Reanimación. 2019;66(5):288–91. DOI: 10.1016/j.redar.2018.12.005
69. Wagdy K, ElMaghawry M. Takotsubo cardiomyopathy: A potentially serious trap (Data from the International Takotsubo Cardiomyopathy Registry). Global Cardiology Science and Practice. 2015;2015(4):55. DOI: 10.5339/gcsp.2015.55
70. Schneider B, Athanasiadis A, Schwab J, Pistner W, Gottwald U, Schoeller R et al. Complications in the clinical course of takotsubo cardiomyopathy. International Journal of Cardiology. 2014;176(1):199– 205. DOI: 10.1016/j.ijcard.2014.07.002
71. Stiermaier T, Eitel C, Desch S, Fuernau G, Schuler G, Thiele H et al. Incidence, determinants and prognostic relevance of cardiogenic shock in patients with Takotsubo cardiomyopathy. European Heart Journal: Acute Cardiovascular Care. 2016;5(6):489–96. DOI: 10.1177/2048872615612456
72. Izumo M, Shiota M, Nalawadi S, Das J, Dohad S, Kuwahara E et al. Determinants of Secondary Pulmonary Hypertension in Patients with Takotsubo Cardiomyopathy. Echocardiography. 2015;32(11):1608– 13. DOI: 10.1111/echo.12949
73. Roghi A, Pedrotti P, Milazzo A, Bonacina E, Bucciarelli-Ducci C. Adrenergic Myocarditis in Pheochromocytoma. Journal of Cardiovascular Magnetic Resonance. 2011;13(1):4. DOI: 10.1186/1532-429X-13-4
74. de Miguel V, Arias A, Paissan A, de Arenaza DP, Pietrani M, Jurado A et al. Catecholamine-Induced Myocarditis in Pheochromocytoma. Circulation. 2014;129(12):1348–9. DOI: 10.1161/CIRCULATIONAHA.113.002762
75. Begieneman MPV, Emmens RW, Rijvers L, Kubat B, Paulus WJ, Vonk ABA et al. Ventricular myocarditis coincides with atrial myocarditis in patients. Cardiovascular Pathology. 2016;25(2):141–8. DOI: 10.1016/j.carpath.2015.12.001
76. Davide Muratori, Patrizia Pedrotti, Matteo Baroni, Armando Belloni, Giuseppina Quattrocchi, Angela Milazzo et al. Miocardite indotta da catecolamine in feocromocitoma. Giornale Italiano di Cardiologia. 2017;18(2):164–8. DOI: 10.1714/2663.27302
77. Wittstein IS, Thiemann DR, Lima JAC, Baughman KL, Schulman SP, Gerstenblith G et al. Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress. New England Journal of Medicine. 2005;352(6):539–48. DOI: 10.1056/NEJMoa043046
78. Iacucci I, Carbone I, Cannavale G, Conti B, Iampieri I, Rosati R et al. Myocardial oedema as the sole marker of acute injury in Takotsubo cardiomyopathy: a cardiovascular magnetic resonance (CMR) study. La radiologia medica. 2013;118(8):1309–23. DOI: 10.1007/s11547- 013-0931-1
79. Madhavan M, Borlaug BA, Lerman A, Rihal CS, Prasad A. Stress hormone and circulating biomarker profile of apical ballooning syndrome (Takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels. Heart. 2009;95(17):1436–41. DOI: 10.1136/hrt.2009.170399
80. Song BG, Yang HS, Hwang HK, Kang GH, Park YH, Chun WJ et al. The Impact of Stressor Patterns on Clinical Features in Patients With Tako-tsubo Cardiomyopathy: Experiences of Two Tertiary Cardiovascular Centers. Clinical Cardiology. 2012;35(11):E6–13. DOI: 10.1002/clc.22053
81. Eitel I, Lücke C, Grothoff M, Sareban M, Schuler G, Thiele H et al. Inflammation in takotsubo cardiomyopathy: insights from cardiovascular magnetic resonance imaging. European Radiology. 2010;20(2):422–31. DOI: 10.1007/s00330-009-1549-5
82. Schwarz K, Ahearn T, Srinivasan J, Neil CJ, Scally C, Rudd A et al. Alterations in Cardiac Deformation, Timing of Contraction and Relaxation, and Early Myocardial Fibrosis Accompany the Apparent Recovery of Acute Stress-Induced (Takotsubo) Cardiomyopathy: An End to the Concept of Transience. Journal of the American Society of Echocardiography. 2017;30(8):745–55. DOI: 10.1016/j.echo.2017.03.016
83. Santoro F, Tarantino N, Ferraretti A, Ieva R, Musaico F, Guastafierro F et al. Serum interleukin 6 and 10 levels in Takotsubo cardiomyopathy: Increased admission levels may predict adverse events at followup. Atherosclerosis. 2016;254:28–34. DOI: 10.1016/j.atherosclerosis.2016.09.012
84. Pérez-Castellanos A, Martínez-Sellés M, Mejía-Rentería H, Andrés M, Sionis A, Almendro-Delia M et al. Tako-tsubo Syndrome in Men: Rare, but With Poor Prognosis. Revista Española de Cardiología (English Edition). 2018;71(9):703–8. DOI: 10.1016/j.rec.2017.07.021
85. Ghadri JR, Ruschitzka F, Lüscher TF, Templin C. Takotsubo cardiomyopathy: still much more to learn. Heart. 2014;100(22):1804–12. DOI: 10.1136/heartjnl-2013-304691
86. Nasr DM, Tomasini S, Prasad A, Rabinstein AA. Acute Brain Diseases as Triggers for Stress Cardiomyopathy: Clinical Characteristics and Outcomes. Neurocritical Care. 2017;27(3):356–61. DOI: 10.1007/s12028-017-0412-9
87. Chong C-R, Neil CJ, Nguyen TH, Stansborough J, Law GW, Singh K et al. Dissociation Between Severity of Takotsubo Cardiomyopathy and Presentation With Shock or Hypotension: Hypotension in Takotsubo cardiomyopathy. Clinical Cardiology. 2013;36(7):401–6. DOI: 10.1002/clc.22129
88. Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nakamura S et al. Time Course of Electrocardiographic Changes in Patients With TakoTsubo Syndrome. Circulation Journal. 2004;68(1):77–81. DOI: 10.1253/circj.68.77
89. Santoro F, Stiermaier T, Tarantino N, Guastafierro F, Graf T, Möller C et al. Impact of persistent ST elevation on outcome in patients with Takotsubo syndrome. Results from the GErman Italian STress Cardiomyopathy (GEIST) registry. International Journal of Cardiology. 2018;255:140–4. DOI: 10.1016/j.ijcard.2017.11.068
90. Rosu D, Askandar S, Khouzam RN. Why Is Reverse Takotsubo “Reverse”? Southern Medical Journal. 2017;110(5):381–5. DOI: 10.14423/SMJ.0000000000000652
91. Agrawal S, Shirani J, Garg L, Singh A, Longo S, Longo A et al. Pheochromocytoma and stress cardiomyopathy: Insight into pathogenesis. World Journal of Cardiology. 2017;9(3):255–60. DOI: 10.4330/wjc.v9.i3.255
92. Imran TF, Rahman I, Dikdan S, Shah R, Niazi OT, Thirunahari N et al. QT Prolongation and Clinical Outcomes in Patients with Takotsubo Cardiomyopathy. Pacing and Clinical Electrophysiology. 2016;39(6):607–11. DOI: 10.1111/pace.12864
93. Lee J-H, Uhm J-S, Shin DG, Joung B, Pak H-N, Ko Y-G et al. Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy. The Korean Journal of Internal Medicine. 2016;31(3):507–16. DOI: 10.3904/kjim.2015.330
94. Jesel L, Berthon C, Messas N, Lim HS, Girardey M, Marzak H et al. Ventricular arrhythmias and sudden cardiac arrest in Takotsubo cardiomyopathy: Incidence, predictive factors, and clinical implications. Heart Rhythm. 2018;15(8):1171–8. DOI: 10.1016/j.hrthm.2018.04.002
95. Stiermaier T, Rommel K-P, Eitel C, Möller C, Graf T, Desch S et al. Management of arrhythmias in patients with Takotsubo cardiomyopathy: Is the implantation of permanent devices necessary? Heart Rhythm. 2016;13(10):1979–86. DOI: 10.1016/j.hrthm.2016.06.013
96. Dote K, Sato H, Tateishi H, Uchida T, Ishihara M. Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases. Journal of Cardiology. 1991;21(2):203–14. PMID: 1841907
97. Bybee KA, Kara T, Prasad A, Lerman A, Barsness GW, Wright RS et al. Systematic Review: Transient Left Ventricular Apical Ballooning: A Syndrome That Mimics ST-Segment Elevation Myocardial Infarction. Annals of Internal Medicine. 2004;141(11):858–65. DOI: 10.7326/0003-4819-141-11-200412070-00010
98. Hoyt J, Lerman A, Lennon RJ, Rihal CS, Prasad A. Left anterior descending artery length and coronary atherosclerosis in apical ballooning syndrome (Takotsubo/stress induced cardiomyopathy). International Journal of Cardiology. 2010;145(1):112–5. DOI: 10.1016/j.ijcard.2009.06.018
99. Azzarelli S, Galassi AR, Amico F, Giacoppo M, Argentino V, Tomasello SD et al. Clinical Features of Transient Left Ventricular Apical Ballooning. The American Journal of Cardiology. 2006;98(9):1273–6. DOI: 10.1016/j.amjcard.2006.05.065
100. Tarkin JM, Khetyar M, Kaski JC. Management of Tako-tsubo Syndrome. Cardiovascular Drugs and Therapy. 2008;22(1):71–7. DOI: 10.1007/s10557-007-6074-7
101. Meimoun P, Malaquin D, Benali T, Boulanger J, Zemir H, Tribouilloy C. Transient impairment of coronary flow reserve in tako-tsubo cardiomyopathy is related to left ventricular systolic parameters. European Journal of Echocardiography. 2008;10(2):265–70. DOI: 10.1093/ejechocard/jen222
102. Sganzerla P, Alioto G, Funaro A, Passaretti B, Borghini E, Guglielmetto S. Transthoracic Doppler ultrasound coronary flow reserve evaluation: preliminary insights into pathophysiology of Takotsubo cardiomyopathy: Journal of Cardiovascular Medicine. 2008;9(12):1229–34. DOI: 10.2459/JCM.0b013e328313e890
103. Абдрахманова А.И., Сайфуллина Г.Б., Амиров Н.Б. Место перфузионной сцинтиграфии миокарда в диагностике синдрома такотсубо. Российский Кардиологический Журнал. 2018;23(12):125-30. DOI: 10.15829/1560-4071-2018-12-125-130
104. Mitchell JH, Hadden TB, Wilson JM, Achari A, Muthupillai R, Flamm SD. Clinical Features and Usefulness of Cardiac Magnetic Resonance Imaging in Assessing Myocardial Viability and Prognosis in Takotsubo Cardiomyopathy (Transient Left Ventricular Apical Ballooning Syndrome). The American Journal of Cardiology. 2007;100(2):296–301. DOI: 10.1016/j.amjcard.2007.02.091
105. Haghi D, Fluechter S, Suselbeck T, Kaden JJ, Borggrefe M, Papavassiliu T. Cardiovascular magnetic resonance findings in typical versus atypical forms of the acute apical ballooning syndrome (Takotsubo cardiomyopathy). International Journal of Cardiology. 2007;120(2):205–11. DOI: 10.1016/j.ijcard.2006.09.019
106. Eitel I, von Knobelsdorff-Brenkenhoff F, Bernhardt P, Carbone I, Muellerleile K, Aldrovandi A et al. Clinical Characteristics and Cardiovascular Magnetic Resonance Findings in Stress (Takotsubo) Cardiomyopathy. JAMA. 2011;306(3):277–286. DOI: 10.1001/jama.2011.992
107. Abanador-Kamper N, Kamper L, Wolfertz J, Pomjanski W, WolfPütz A, Seyfarth M. Evaluation of therapy management and outcome in Takotsubo syndrome. BMC Cardiovascular Disorders. 2017;17(1):225. DOI: 10.1186/s12872-017-0661-8
108. Sharkey SW, Lesser JR, Menon M, Parpart M, Maron MS, Maron BJ. Spectrum and Significance of Electrocardiographic Patterns, Troponin Levels, and Thrombolysis in Myocardial Infarction Frame Count in Patients With Stress (Tako-tsubo) Cardiomyopathy and Comparison to Those in Patients With ST-Elevation Anterior Wall Myocardial Infarction. The American Journal of Cardiology. 2008;101(12):1723– 8. DOI: 10.1016/j.amjcard.2008.02.062
109. Pilgrim TM, Wyss TR. Takotsubo cardiomyopathy or transient left ventricular apical ballooning syndrome: A systematic review. International Journal of Cardiology. 2008;124(3):283–92. DOI: 10.1016/j.ijcard.2007.07.002
110. Tarantino N, Santoro F, Guastafierro F, Di Martino LFM, Scarcia M, Ieva R et al. “Lambda-wave” ST-elevation is associated with severe prognosis in stress (takotsubo) cardiomyopathy. Annals of Noninvasive Electrocardiology. 2018;23(6):e12581. DOI: 10.1111/anec.12581
111. Akashi YJ, Musha H, Kida K, Itoh K, Inoue K, Kawasaki K et al. Reversible ventricular dysfunction takotsubo cardiomyopathy. European Journal of Heart Failure. 2005;7(7):1171–6. DOI: 10.1016/j.ejheart.2005.03.011
112. Jim M-H, Chan AO-O, Tsui P-T, Lau S-T, Siu C-W, Chow W-H et al. A new ECG criterion to identify takotsubo cardiomyopathy from anterior myocardial infarction: role of inferior leads. Heart and Vessels. 2009;24(2):124–30. DOI: 10.1007/s00380-008-1099-9
113. Madias JE. Prevalence of Comorbidities in Patients with Takotsubo Syndrome. The American Journal of Medicine. 2015;128(8):e19. DOI: 10.1016/j.amjmed.2015.02.022
114. Pelliccia F, Parodi G, Greco C, Antoniucci D, Brenner R, Bossone E et al. Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients. The American Journal of Medicine. 2015;128(6):654.e11-654.e19. DOI: 10.1016/j.amjmed.2015.01.016
115. Rueda D, Aguirre R, Contardo D, Finocchietto P, Hernandez S, di Fonzo H. Takotsubo Myocardiopathy and Hyperthyroidism: A Case Report and Literature Review. American Journal of Case Reports. 2017;18:865–70. DOI: 10.12659/AJCR.905121
116. Murdoch D, O’Callaghan W, Reda E, Niranjan S. Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter. International Journal of Angiology. 2015;25(05):e121–2. DOI: 10.1055/s-0035-1548548
117. Omar S, Ali E, Mazek H, Mahmood T, Soontrapa S, Suarez J. Takotsubo Cardiomyopathy Associated with Hyperthyroidism Treated with Thyroidectomy. Baylor University Medical Center Proceedings. 2015;28(2):194–5. DOI: 10.1080/08998280.2015.11929227
118. Eliades M, El-Maouche D, Choudhary C, Zinsmeister B, Burman KD. Takotsubo Cardiomyopathy Associated with Thyrotoxicosis: A Case Report and Review of the Literature. Thyroid. 2014;24(2):383–9. DOI: 10.1089/thy.2012.0384
119. Rubio A, Raasmaja A, Maia AL, Kim KR, Silva JE. Effects of thyroid hormone on norepinephrine signaling in brown adipose tissue. I. Beta 1- and beta 2-adrenergic receptors and cyclic adenosine 3’,5’-monophosphate generation. Endocrinology. 1995;136(8):3267–76. DOI: 10.1210/endo.136.8.7628360
120. Rubio A, Raasmaja A, Silva JE. Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. Endocrinology. 1995;136(8):3277–84. DOI: 10.1210/endo.136.8.7628361
121. Tamaki T, Node Y, Teramoto A. Changes of the plasma ketone body level and arterial ketone body ratio at the onset of mild aneurysmal subarachnoid hemorrhage. Neurological Research. 2008;30(9):898– 902. DOI: 10.1179/016164108X323708
122. Redfors B, Vedad R, Angerås O, Råmunddal T, Petursson P, Haraldsson I et al. Mortality in takotsubo syndrome is similar to mortality in myocardial infarction — A report from the SWEDEHEART registry. International Journal of Cardiology. 2015;185:282–9. DOI: 10.1016/j.ijcard.2015.03.162
123. Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nakama Y et al. Prevalence of incidental coronary artery disease in tako-tsubo cardiomyopathy: Coronary Artery Disease. 2009;20(3):214–8. DOI: 10.1097/MCA.0b013e3283299260
124. Lazzeroni D, Bini M, Castiglioni P, Moderato L, Ciracì C, Camaiora U et al. Anxiety disorders and stressful events in Takotsubo syndrome. Cardiology Journal. 2018;25(4):495–500. DOI: 10.5603/CJ.a2017.0136
125. Dias A, Franco E, Mercedes A, Hebert K, Messina D, Quevedo HC. Clinical Features of Takotsubo Cardiomyopathy - A Single-Center Experience. Cardiology. 2013;126(2):126–30. DOI: 10.1159/000353369
126. El-Sayed AM, Brinjikji W, Salka S. Demographic and Co-Morbid Predictors of Stress (Takotsubo) Cardiomyopathy. The American Journal of Cardiology. 2012;110(9):1368–72. DOI: 10.1016/j.amjcard.2012.06.041
127. Burgdorf C, Kurowski V, Bonnemeier H, Schunkert H, Radke PW. Long-term prognosis of the transient left ventricular dysfunction syndrome (Tako-Tsubo cardiomyopathy): Focus on malignancies. European Journal of Heart Failure. 2008;10(10):1015–9. DOI: 10.1016/j.ejheart.2008.07.008
128. Madias JE. Low prevalence of diabetes mellitus in patients with Takotsubo syndrome: A plausible ‘protective’ effect with pathophysiologic connotations. European Heart Journal: Acute Cardiovascular Care. 2016;5(2):164–70. DOI: 10.1177/2048872615570761
129. Bill V, El-Battrawy I, Behnes M, Baumann S, Becher T, Elmas E et al. “Diabetes paradox” in Takotsubo Cardiomyopathy. International Journal of Cardiology. 2016;224:88–9. DOI: 10.1016/j.ijcard.2016.08.136
130. Stiermaier T, Santoro F, El-Battrawy I, Möller C, Graf T, Novo G et al. Prevalence and Prognostic Impact of Diabetes in Takotsubo Syndrome: Insights From the International, Multicenter GEIST Registry. Diabetes Care. 2018;41(5):1084–8. DOI: 10.2337/dc17-2609
131. Montenegro Sá F, Ruivo C, Santos LG, Antunes A, Saraiva F, Soares F et al. Myocardial infarction with nonobstructive coronary arteries: a single-center retrospective study. Coronary Artery Disease. 2018;29(6):511–5. DOI: 10.1097/MCA.0000000000000619
132. Рябов В.В., Гомбоева С.Б., Шелковникова Т.А., Баев А.Е., Ребенкова М.С., Роговская Ю.В. и др. Магнитно-резонансная томография сердца в дифференциальной диагностике острого коронарного синдрома у больных необструктивным коронарным атеросклерозом. Российский кардиологический журнал. 2017;22(12):47-54. DOI: 10.15829/1560-4071-2017-12-47-54
133. Рябов В.В., Федорова С.Б., Вышлов Е.В. Инфаркт миокарда без обструктивного коронарного атеросклероза—актуальная проблема неотложной кардиологии. Сибирский Медицинский Журнал. 2019;33(4):10–8. DOI: 10.29001/2073-8552-2018-33-4-10-18
134. Schlossbauer SA, Ghadri JR, Scherff F, Templin C. The challenge of Takotsubo syndrome: heterogeneity of clinical features. Swiss Medical Weekly. 2017;147:w14490. DOI: 10.4414/smw.2017.14490
135. Del Buono MG, Potere N, Chiabrando JG, Bressi E, Abbate A. Takotsubo syndrome: diagnostic work-up and clues into differential diagnosis. Current Opinion in Cardiology. 2019;34(6):673–86. DOI: 10.1097/HCO.0000000000000672
136. Tamis-Holland JE, Jneid H, Reynolds HR, Agewall S, Brilakis ES, Brown TM et al. Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association. Circulation. 2019;139(18):e891–908. DOI: 10.1161/CIR.0000000000000670
137. Montone RA, Niccoli G, Fracassi F, Russo M, Gurgoglione F, Cammà G et al. Patients with acute myocardial infarction and non-obstructive coronary arteries: safety and prognostic relevance of invasive coronary provocative tests. European Heart Journal. 2018;39(2):91–8. DOI: 10.1093/eurheartj/ehx667
138. Akashi YJ, Musha H, Nakazawa K, Miyake F. Plasma brain natriuretic peptide in takotsubo cardiomyopathy. QJM. 2004;97(9):599–607. DOI: 10.1093/qjmed/hch094
139. Budnik M, Kochanowski J, Piatkowski R, Wojtera K, Peller M, Gaska M et al. Simple markers can distinguish Takotsubo cardiomyopathy from ST segment elevation myocardial infarction. International Journal of Cardiology. 2016;219:417–20. DOI: 10.1016/j.ijcard.2016.06.015
140. Nef HM, Möllmann H, Weber M, Deetjen A, Brandt R, Hamm CW et al. Release pattern of cardiac biomarkers in left ventricular apical ballooning. International Journal of Cardiology. 2007;115(1):128–9. DOI: 10.1016/j.ijcard.2006.01.034
141. Stiermaier T, Santoro F, Graf T, Guastafierro F, Tarantino N, De Gennaro L et al. Prognostic value of N-Terminal Pro-B-Type Natriuretic Peptide in Takotsubo syndrome. Clinical Research in Cardiology. 2018;107(7):597–606. DOI: 10.1007/s00392-018-1227-1
142. Randhawa MS, Dhillon AS, Taylor HC, Sun Z, Desai MY. Diagnostic Utility of Cardiac Biomarkers in Discriminating Takotsubo Cardiomyopathy From Acute Myocardial Infarction. Journal of Cardiac Failure. 2014;20(1):2–8. DOI: 10.1016/j.cardfail.2013.12.004
143. Ito K, Sugihara H, Kinoshita N, Azuma A, Matsubara H. Assessment of Takotsubo cardiomyopathy (transient left ventricular apical ballooning) using 99mTc-tetrofosmin, 123I-BMIPP, 123I-MIBG and 99mTc-PYP myocardial SPECT. Annals of Nuclear Medicine. 2005;19(6):435–45. DOI: 10.1007/BF02985570
144. Nakamura M, Onoguchi M, Shibutani T. Prediction of long-term cardiac events by 123I-MIBG imaging after acute myocardial infarction and reperfusion therapy. Asia Oceania Journal of Nuclear Medicine and Biology. 2019;7(2):121–128. DOI: 10.22038/aojnmb.2019.33991.1236
145. Minamisawa M, Izawa A, Motoki H, Kashima Y, Hioki H, Abe N et al. Prognostic Significance of Neuroadrenergic Dysfunction for Cardiovascular Events in Patients With Acute Myocardial Infarction. Circulation Journal. 2015;79(10):2238–45. DOI: 10.1253/circj.CJ-15-0265
146. Langhans B, Nadjiri J, Jähnichen C, Kastrati A, Martinoff S, Hadamitzky M. Reproducibility of area at risk assessment in acute myocardial infarction by T1- and T2-mapping sequences in cardiac magnetic resonance imaging in comparison to Tc99m-sestamibi SPECT. The International Journal of Cardiovascular Imaging. 2014;30(7):1357–63. DOI: 10.1007/ s10554-014-0467-z
147. Christensen TE, Bang LE, Holmvang L, Ghotbi AA, Lassen ML, Andersen F et al. Cardiac 99mTc sestamibi SPECT and 18F FDG PET as viability markers in takotsubo cardiomyopathy. The International Journal of Cardiovascular Imaging. 2014;30(7):1407–16. DOI: 10.1007/s10554-014-0453-5
При поддержке: Работа выполнена при поддержке Российского научного фонда грант 21‑15‑00037. Раздел, посвященный BNP при синдроме такотсубо, выполнен в рамках государственного задания АААА-А15‑115120910024‑0. Конфликт интересов не заявлен.
Для цитирования:
Прокудина Е.С., Курбатов Б.К., Маслов Л.Н. Клиническая картина стрессорной кардиомиопатии (синдром такотсубо) и проблема дифференциальной диагностики с острым инфарктом миокарда. Кардиология. 2020;60(11):137–147. https://doi.org/10.18087/cardio.2020.11.n777
For citation:
Prokudina E.S., Kurbatov B.K., Maslov L.N. Clinical Manifestation of Stressful Cardiomyopathy (Takotsubo Syndrome) and the Problem of Differential Diagnosis with Acute Myocardial Infarction. Kardiologiia. 2020;60(11):137–147. (In Russ.) https://doi.org/10.18087/cardio.2020.11.n777
Просмотров: 328
Послать статью по эл. почте 
Оставить комментарий 