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sST2- биомаркер для оценки прогноза и мониторирования больных декомпенсированной сердечной недостаточностью

https://doi.org/10.18087/cardio.n765

Полный текст:

Аннотация

Обзорная статья посвящена значению определения концентраций нового биомаркера sST2 для оценки прогноза и мониторирования эффективности лечения больных декомпенсированной сердечной недостаточностью во время эпизода декомпенсации и при длительном наблюдении после выписки из стационара. В статье детально проанализирована целесообразность определения концентраций sST2 у больного ОДСН во время госпитализации, при поступлении и выписке из клиники, показано значение изменения уровня биомаркера за период активного лечения для стратификации риска пациентов, представлены оптимальные пороговые значения sST2, на которые следует ориентироваться при выделении больных высокого и очень высокого риска. Подчеркнута важность последующего мониторирования концентрации маркера при длительном наблюдении для предопределения риска развития смерти, повторной декомпенсации/госпитазизации из-за СН, показаны потенциальные преимущества выбора sST2 в качестве наиболее оптимального маркера для серийного измерения при длительном наблюдении, также как и оценки эффективности проводимого лечения больных СН по сравнению с «классическим» вариантом – натрийуретическими пептидами.

Ключевые слова


Об авторах

А. А. Скворцов
ФГБУ "НМИЦ кардиологии" Минздрава России
Россия
121552, Москва, ул. 3-я Черепковская, 15а


О. Ю. Нарусов
ФГБУ "НМИЦ кардиологии" Минздрава России
Россия
121552, Москва, ул. 3-я Черепковская, 15а


М. Д. Муксинова
ФГБУ "НМИЦ кардиологии" Минздрава России
Россия
121552, Москва, ул. 3-я Черепковская, 15а


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Для цитирования:


Скворцов А.А., Нарусов О.Ю., Муксинова М.Д. sST2- биомаркер для оценки прогноза и мониторирования больных декомпенсированной сердечной недостаточностью. Кардиология. 2019;59(11S):18-27. https://doi.org/10.18087/cardio.n765

For citation:


Skvortsov A.A., Narusov O.Y., Muksinova M.D. Soluble ST2 – biomarker for prognosis and monitoring in decompensated heart failure. Kardiologiia. 2019;59(11S):18-27. (In Russ.) https://doi.org/10.18087/cardio.n765

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