Возможные генетически детерминированные механизмы развития артериальной гипертонии при табакокурении
https://doi.org/10.18087/cardio.2556
Аннотация
Рост распространенности артериальной гипертонии/гипертензии (АГ) в популяциях, недостаточная эффективность лечения, необходимость стратификации рисков, профилактики, ранней диагностики и эффективного лечения актуализируют геномные исследования для разработки персонализированного терапевтического подхода к АГ. В обзоре исследуются возможные генетически детерминированные механизмы развития АГ и эндотелиальной дисфункции, обусловленные полиморфизмом генов эндотелиальной синтазы окиси азота (еNOS) и ферментов фаз I и II системы детоксикации ксенобиотиков. Обсуждается вероятное взаимодействие обеих систем при воздействии вредных экологических факторов, в том числе табакокурения, и в гестационном периоде. Предлагается изучать гены-кандидаты АГ в системе детоксикации ксенобиотиков, носительство различных вариантов которых может определять чувствительность либо резистентность к антигипертензивной фармакотерапии, что может быть полезно для разработки персонализированной тактики ведения больных АГ.
Об авторах
Н. В. МальцеваРоссия
654005, Кемеровская область, г. Новокузнецк, пр. Строителей, 5
А. Ш. Смирнова
Россия
654005, Кемеровская область, г. Новокузнецк, пр. Строителей, 5
А. С. Рублевская
Россия
654005, Кемеровская область, г. Новокузнецк, пр. Строителей, 5
Н. А. Бичан
Россия
654005, Кемеровская область, г. Новокузнецк, пр. Строителей, 5
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Рецензия
Для цитирования:
Мальцева Н.В., Смирнова А.Ш., Рублевская А.С., Бичан Н.А. Возможные генетически детерминированные механизмы развития артериальной гипертонии при табакокурении. Кардиология. 2019;59(1S):4-10. https://doi.org/10.18087/cardio.2556
For citation:
Maltseva N.V., Smirnova A.S., Rublevskaya A.C., Bichan N.A. Possible genetically determined mechanisms of arterial hypertension in tobacco smoking. Kardiologiia. 2019;59(1S):4-10. (In Russ.) https://doi.org/10.18087/cardio.2556