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Кардиология

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Ишемическая болезнь сердца у лиц молодого возраста: особенности этиологии, клинических проявлений и прогноза

https://doi.org/10.18087/cardio.2018.11.10195

Полный текст:

Аннотация

У больных молодого возраста с ишемической болезнью сердца (ИБС), помимо традиционных факторов риска развития сердечно-сосудистых заболеваний, важную роль играет ряд других предрасполагающих факторов, в том числе генетических. Молекулярно-генетическая диагностика используется для обнаружения моногенных заболеваний с высоким риском развития ИБС, таких как семейная гиперхолестеринемия. Для уточнения риска развития ИБС у больных без симптомов заболевания осуществляются попытки учета совокупности однонуклеотидных полиморфизмов, объединенных в шкалы генетического риска. У больных молодого возраста первым проявлением ИБС чаще становится острый коронарный синдром, чаще обнаруживают неизмененные или малоизмененные коронарные артерии и однососудистые поражения, а примерно в 20% случаев причина ИБС не связана с атеросклерозом. В целом у молодых больных ИБС прогноз лучше, чем у пожилых. При этом существуют гендерные различия в исходах ИБС у больных молодого возраста, причина которых не выяснена.

Об авторах

Е. Ю. Андреенко
ФГБУ «Национальный медицинский исследовательский центр профилактической медицины» Минздрава России
Россия

Москва



И. С. Явелов
ФГБУ «Национальный медицинский исследовательский центр профилактической медицины» Минздрава России
Россия

Москва



М. М. Лукьянов
ФГБУ «Национальный медицинский исследовательский центр профилактической медицины» Минздрава России
Россия

Москва



А. Н. Вернохаева
ФГБУ «Национальный медицинский исследовательский центр профилактической медицины» Минздрава России
Россия

Москва



О. М. Драпкина
ФГБУ «Национальный медицинский исследовательский центр профилактической медицины» Минздрава России
Россия

Москва



С. А. Бойцов
ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России
Россия

Москва



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Для цитирования:


Андреенко Е.Ю., Явелов И.С., Лукьянов М.М., Вернохаева А.Н., Драпкина О.М., Бойцов С.А. Ишемическая болезнь сердца у лиц молодого возраста: особенности этиологии, клинических проявлений и прогноза. Кардиология. 2018;58(11):24-34. https://doi.org/10.18087/cardio.2018.11.10195

For citation:


Andreenko E.Y., Yavelov I.S., Loukianov М.М., Vernohaeva A.N., Drapkina O.M., Boytsov S.A. Ischemic Heart Disease in Subjects of Young Age: Current State of the Problem. Features of Etiology, Clinical Manifestation and Prognosis. Kardiologiia. 2018;58(11):24-34. (In Russ.) https://doi.org/10.18087/cardio.2018.11.10195

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