Клеточная терапия хронической сердечной недостаточности - современное состояние проблемы
Аннотация
Использование аутологичной мононуклеарной фракции костного мозга (или ее производных) для лечения пациентов с ХСН -перспективный метод лечения этой тяжелой и многочисленной группы больных. Анализируются зарубежный и отечественный опыт использования клеточной терапии для лечения больных ХСН и возможность широкого использования аутологичной мононуклеарной фракции костного мозга в клинической практике.
Об авторах
С. А. Белый
ФГБОУ ВО «ПСПбГМУ им. акад. И.П. Павлова» МЗ РФ
Россия
Россия
В. В. Комок
ФГБОУ ВО «ПСПбГМУ им. акад. И.П. Павлова» МЗ РФ
Россия
Россия
Список литературы
1. Cook C., Cole G., Asaria P., Jabbour R., Francis D.P. The annual global economic burden of heart failure. International Journal of Cardiology. 2014; 171 (3): 368-76. DOI: 10.1016/j.ijcard.2013.12.028
2. Mozaffarian D., Benjamin E.J., Go A.S., Arnett D.K., Blaha M.J., Cushman M. et al. Heart Disease and Stroke Statistics - 2016 Update: A Report From the American Heart Association. Circulation. 2016; 133(4): e38-360.DOI: 10.1161/CIR.0000000000000350
3. Jessup M. The Heart Failure Paradox: An Epidemic of Scientific Success: Presidential Address at the American Heart Association 2013 Scientific Sessions. Circulation. 2014; 129 (25): 2717-22. DOI: 10.1161/CIR.0000000000000065
4. Frangogiannis N.G. Pathophysiology of Myocardial Infarction. Terjung R, редактор. Comprehensive Physiology [Интернет]. -Hoboken, NJ, USA: John Wiley & Sons, Inc.; 2015сен20 [цитируется по 10 апрель 2018 г.]. с. 1841-75. ISBN: 978-0-470-65071-4
5. Jennings R.B. Historical Perspective on the Pathology of Myocardial Ischemia/Reperfusion Injury. Circulation Research. 2013; 113 (4): 428-38. DOI: 10.1161/CIRCRESAHA.113.300987
6. Bergmann O., Bhardwaj R.D., Bernard S., Zdunek S., Barnabé-Heider F., Walsh S. et al. Evidence for Cardiomyocyte Renewal in Humans. Science. 2009; 324 (5923): 98-102. DOI: 10.1126/science.1164680
7. Senyo S.E., Steinhauser M.L., Pizzimenti C.L., Yang V.K., Cai L., Wang M. et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature. 2012,493 (7432): 433-6. DOI: 10.1038/nature11682
8. Pfeffer M.A., Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation. 1990, 81 (4): 1161-72. PMID: 2138525
9. Chan W., Duffy S.J., White D.A., Gao X.-M., Du X.-J., Ellims A.H. et al. Acute Left Ventricular Remodeling Following Myocardial Infarction. JACC: Cardiovascular Imaging. 2012,5 (9): 884-93. DOI: 10.1016/j.jcmg.2012.03.015
10. Burchfield J.S., Xie M., Hill J.A. Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2. Circulation. 2013, 128 (4): 388-400. DOI: 10.1161/CIRCULATIONAHA.113.001878
11. Xie M., Burchfield J.S., Hill J.A. Pathological Ventricular Remodeling: Therapies: Part 2 of 2. Circulation. 2013, 128 (9): 1021-30. DOI: 10.1161/CIRCULATIONAHA.113.001879
12. Jugdutt B.I. Ventricular Remodeling After Infarction and the Extracellular Collagen Matrix: When Is Enough Enough? Circulation. 2003, 108 (11): 1395-403. DOI: 10.1161/01.CIR.0000085658.98621.49
13. Wilcox J.E., Fonarow G.C., Ardehali H., Bonow R.O., Butler J., Sauer A.J. et al. «Targeting the Heart» in Heart Failure. JACC: Heart Failure. 2015,3 (9): 661-9. DOI: 10.1016/j.jchf.2015.04.011
14. Tseng C.C.S., Ramjankhan F.Z., de Jonge N., Chamuleau S.A.J. Advanced Strategies for End-Stage Heart Failure: Combining Regenerative Approaches with LVAD, a New Horizon? Frontiers in Surgery [Интернет]. 2015 [цитируется по 10 апрель 2018 г.], 2. DOI: 10.3389/fsurg.2015.00010
15. Gheorghiade M., Larson C.J., Shah S.J., Greene S.J., Cleland J.G.F., Colucci W.S. et al. Developing New Treatments for Heart Failure: Focus on the Heart. Circulation: Heart Failure. 2016,9 (5): e002727. DOI: 10.1161/CIRCHEARTFAILURE.115.002727
16. Braunwald E. Research Advances in Heart Failure: A Compendium. Circulation Research. 2013,113 (6): 633-45. DOI: 10.1161/CIRCRESAHA.113.302254
17. Pompilio G., Nigro P., Bassetti B., Capogrossi M.C. Bone Marrow Cell Therapy for Ischemic Heart Disease: Figure.: The Never Ending Story. Circulation Research. 2015, 117 (6): 490-3. DOI: 10.1161/CIRCRESAHA. 115.307184
18. Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Li B. et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001,410 (6829): 701-5. DOI: 10.1038/35070587
19. Orlic D., Kajstura J., Chimenti S., Bodine D.M., Leri A., Anversa P. Bone marrow stem cells regenerate infarcted myocardium. Pediatr Transplant. 2003, 7 Suppl 3: 86-8. PMID: 12603699
20. Kubal C., Sheth K., Nadal-Ginard B., Galinanes M. Bone marrow cells have a potent anti-ischemic effect against myocardial cell death in humans. The Journal of Thoracic and Cardiovascular Surgery. 2006, 132 (5): 1112-8. DOI: 10.1016/j.jtcvs.2006.06.028
21. Duran J.M., Makarewich C.A., Sharp T.E., Starosta T., Zhu F., Hoffman N.E. et al. Bone-Derived Stem Cells Repair the Heart After Myocardial Infarction Through Transdifferentiation and Paracrine Signaling Mechanisms. Circulation Research. 2013,113 (5): 539-52. DOI: 10.1161/CIRCRESAHA.113.301202
22. Protti A., Mongue-Din H., Mylonas K.J., Sirker A., Sag C.M., Swim M.M. et al. Bone marrow transplantation modulates tissue macrophage phenotype and enhances cardiac recovery after subsequent acute myocardial infarction. Journal of Molecular and Cellular Cardiology. 2016, 90: 120-8. DOI: 10.1016/j.yjmcc.2015.12.007
23. Karantalis V., Balkan W., Schulman I.H., Hatzistergos K.E., Hare J.M. Cell-based therapy for prevention and reversal of myocardial remodeling. American Journal of Physiology-Heart and Circulatory Physiology. 2012,303 (3): H256-70. DOI: 10.1152/ajpheart.00221.2012
24. Nahrendorf M., Pittet M.J., Swirski F.K. Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction. Circulation. 2010, 121 (22): 2437-45. DOI: 10.1161/CIRCULATIONAHA.109.916346
25. Ben-Mordechai T., Holbova R., Landa-Rouben N., Harel-Adar T., Feinberg M.S., Abd Elrahman I. et al. Macrophage Subpopulations Are Essential for Infarct Repair With and Without Stem Cell Therapy. Journal of the American College of Cardiology. 2013,62 (20): 1890-901. DOI: 10.1016/j.jacc.2013.07.057
26. Wynn T.A., Vannella K.M. Macrophages in Tissue Repair, Regeneration, and Fibrosis. Immunity. 2016,44 (3): 450-62. DOI: 10.1016/j.immuni. 2016.02.015
27. Cheng K., Wu F., Cao F. Intramyocardial Autologous Cell Engraftment in Patients with Ischaemic Heart Failure: A Meta-Analysis of Randomised Controlled Trials. Heart, Lung and Circulation. 2013, 22 (11): 887-94. DOI: 10.1016/j.hlc.2013.04.112
28. Donndorf P., Kundt G., Kaminski A., Yerebakan C., Liebold A., Steinhoff G. et al. Intramyocardial bone marrow stem cell transplantation during coronary artery bypass surgery: A meta-analysis. The Journal of Thoracic and Cardiovascular Surgery. 2011,142 (4): 911-20. DOI: 10.1016/j.jtcvs.2010.12.013
29. Fisher S.A., Brunskill S.J., Doree C., Mathur A., Taggart D.P., Martin-Rendon E. Stem cell therapy for chronic ischaemic heart disease and congestive heart failure. The Cochrane Collaboration, редактор. Cochrane Database of Systematic Reviews [Интернет]. -Chichester, UK: John Wiley & Sons, Ltd, 2014апр29 [цитируется по 10 апрель 2018 г.].
30. Jeevanantham V., Butler M., Saad A., Abdel-Latif A., Zuba-Surma E.K., Dawn B. Adult Bone Marrow Cell Therapy Improves Survival and Induces Long-Term Improvement in Cardiac Parameters: A Systematic Review and Meta-Analysis. Circulation. 2012, 126 (5): 551-68. DOI: 10.1161/CIRCULATIONAHA. =111.086074
31. Jiang M., He B., Zhang Q., Ge H., Zang M.H., Han Z.H. et al. Randomized controlled trials on the therapeutic effects of adult progenitor cells for myocardial infarction: meta-analysis. Expert Opinion on Biological Therapy. 2010,10 (5): 667-80. DOI: 10.1517/14712591003716437
32. Kandala J., Upadhyay G.A., Pokushalov E., Wu S., Drachman D.E., Singh J.P. Meta-Analysis of Stem Cell Therapy in Chronic Ischemic Cardiomyopathy. The American Journal of Cardiology. 2013,112 (2): 217-25. DOI: 10.1016/j.amjcard.2013.03.021
33. Sadat K., Ather S., Aljaroudi W., Heo J., Iskandrian A.E., Hage F.G. The effect of bone marrow mononuclear stem cell therapy on left ventricular function and myocardial perfusion. Journal of Nuclear Cardiology. 2014, 21 (2): 351-67. DOI: 10.1007/s12350-013-9846-4
34. Tian T, Chen B., Xiao Y., Yang K., Zhou X. Intramyocardial autologous bone marrow cell transplantation for ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials. Atherosclerosis. 2014, 233 (2): 485-92. DOI: 10.1016/j.atherosclerosis.2014.01.027
35. Wen Y., Meng L., Xie J., Ouyang J. Direct autologous bone marrow-derived stem cell transplantation for ischemic heart disease: a meta-analysis. Expert Opinion on Biological Therapy. 2011,11 (5): 559-67. DOI: 10.1517/14712598.2011.560567
36. Xu R., Ding S., Zhao Y., Pu J., He B. Autologous Transplantation of Bone Marrow/Blood-Derived Cells for Chronic Ischemic Heart Disease: A Systematic Review and Meta-analysis. Canadian Journal of Cardiology. 2014,30 (11): 1370-7. DOI: 10.1016/j.cjca.2014.01.013
37. Zhao Q., Ye X. Additive value of adult bone-marrow-derived cell transplantation to conventional revascularization in chronic ischemic heart disease: a systemic review and meta-analysis. Expert Opinion on Biological Therapy. 2011, 11 (12): 1569-79. DOI: 10.1517/14712598.20 11.616491
38. Fisher S.A., Doree C., Mathur A., Martin-Rendon E. Meta-Analysis of Cell Therapy Trials for Patients With Heart Failure. Circulation Research. 2015, 116 (8): 1361-77. DOI: 10.1161/CIRCRESAHA.116.304386
39. Afzal M.R., Samanta A., Shah Z.I., Jeevanantham V., Abdel-Lati A., Zuba-Surma E.K. et al. Adult Bone Marrow Cell Therapy for Ischemic Heart DiseaseNovelty and Significance: Evidence and Insights From Randomized Controlled Trials. Circulation Research. 2015,117 (6): 558-75. DOI: 10.1161/CIRCRESAHA.114.304792
40. Fisher S.A., Doree C., Mathur A., Taggart D.P., Martin-Rendon E. Stem cell therapy for chronic ischaemic heart disease and congestive heart failure. Cochrane Heart Group, редактор. Cochrane Database of Systematic Reviews [Интернет]. 2016 [цитируется по 10 апрель 2018 г.], DOI: 10.1002/14651858.CD007888. pub3
41. Martin-Rendon E. Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies Response to Martin-Rendon: What Can Systematic Reviews Tell Us About Cell Therapies for Ischemic Heart Disease? Circulation Research. 2016; 118 (8): 1264-72. DOI: 10.1161/CIRCRESAHA.115.307540
42. Pokushalov E., Romanov A., Chernyavsky A., Larionov P., Terekhov I., Artyomenko S. et al. Efficiency ofIntramyocardial Injections ofAutolo-gous Bone Marrow Mononuclear Cells in Patients with Ischemic Heart Failure: A Randomized Study. Journal of Cardiovascular Translational Research. 2010; 3 (2): 160-8. DOI: 10.1007/s12265-009-9123-8
43. Чернявский А.М., Кливер Е.Н., Покушалов Е.А., Романов А.Б., Терехов И.Н., Кливер Е.Э. Результаты Интрамиокардиального Введения Мононуклеарной Фракции Аутологичных Клеток Костного Мозга Пациентам С. Ишемической Болезнью Сердца, Осложненной Сердечной Недостаточностью. Вестник Трансплантологии И. Искусственных Органов. 2013; 15 (3): 83-91.
44. Чернявский А.М., Кливер Е.Н., Покушалов Е.А., Кливер Е.Э., Романов А.Б. Отдаленные результаты клеточной терапии ИБС, осложненной С.Н. Сердце: Журнал Для Практикующих Врачей. 2015; 14 (1): 19-24.
45. Кливер Е.Н., Чернявский А.М., Покушалов Е.А., Кливер Е.Э., Романов А.Б., Субботин Д.В. Трехгодовые Результаты Трансэндокардиального Введения Мононуклеарной Фракции Аутологичных Клеток Костного Мозга Пациентам С. Ишемической Болезнью Сердца, Осложненной Сердечной Недостаточностью. Вестник Новосибирского Государственного Университета Серия: Биология, Клиническая Медицина. 2014; 12 (4): 38-43.
46. Комок В.В., Белый С.А., Гриненко О.А., Немков А.С. Клеточные технологии в комбинированном лечении ИБС. Практическая Медицина. 2015; (3-2 (88)): 10-6.
47. Нестерук Ю.А., Немков А.С., Белый С.А., Рыжкова Д.В., Комок В.В. Оценка динамики кровоснабжения и метаболизма миокарда после интракоронарного введения аутологичных мононуклеаров костного мозга. Регионарное Кровообращение И. Микроциркуляция. 2014; 13 (3 (51)): 23-30.
48. Седов В.М., Немков А.С., Белый С.А., Юдина О.В., Бурнос С.Н., Немков А.С. Изменение показателей перфузии миокарда после интракоронарного введения аутологичных мононуклеарных клеток костного мозга больным ИБС. Пятилетнее наблюдение. Регионарное Кровообращение И. Микроциркуляция. 2011; 10 (2): 19-23.
49. Бурнос С.Н., Немков А.С., Белый С.А., Лукашенко В.И. Фракция Выброса И. Размеры Левого Желудочка Сердца После Интракоронарного Введения Аутологичных Мононуклеарных Клеток Костного Мозга У. Больных С. Ишемической Болезнью Сердца Со Сниженной Фракцией Выброса. Вестник Хирургии Им Ии Грекова. 2011; 170 (4): 16-9.
50. Седов В.М., Немков А.С., Афанасьев Б.В., Белый С.А., Зверев О.Г., Бабенко Е.В. и др. Отдалённые Результаты Клинического Применения Аутологичной Мононуклеарной Фракции Костного Мозга Для Регенеративной Терапии Больных С. Ишемической Болезнью Сердца. Вестник Хирургии Им И.И. Грекова. 2012; 171 (5): 11-9.
51. Немков А.С., Белый С.А., Нестерук Ю.А., Бурнос С.Н., Лукашенко В.И., Крейль В.А. и др. Качество Жизни У. Больных С. Ишемической Болезнью Сердца После Применения Клеточной Терапии. Вестник Хирургии Им ИИ Грекова. 2012; 171 (1): 16-20.
52. Немков А.С., Белый С.А., Комок В.В., Атмадзас К.А., Филатов В.И., Рыжкова Д.В. Имплантация Аутологичных Мононуклеаров Костного Мозга Как Первый Этап Комплексного Хирургического Лечения Ишемической Болезни Сердца В. Сочетании С. Аортокоронарным Шунтированием. Вестник Хирургии Им И.И. Грекова. 2015; 174 (6): 85-8.
53. Carson P., Wertheimer J., Miller A., O»Connor C.M., Pina I.L., Selzman C. et al. The STICH Trial (Surgical Treatment for Ischemic Heart Failure). JACC: Heart Failure. 2013; 1 (5): 400-8. DOI: 10.1016/j.jchf.2013.04.012
54. Petrie M.C., Jhund P.S., She L., Adlbrecht C., Doenst T., Panza J.A. et al. Ten-Year Outcomes After Coronary Artery Bypass Grafting According to Age in Patients With Heart Failure and Left Ventricular Systolic Dysfunction Clinical Perspective: An Analysis of the Extended Follow-Up of the STICH Trial (Surgical Treatment for Ischemic Heart Failure). Circulation. 2016; 134 (18): 1314-24. DOI: 10.1161/CIR-CULATIONAHA.116.024800
55. Briceno N., Perera D. To Revascularise or Not To Revascularise, That Is the Question: the Diagnostic and Management Conundrum of Ischaemic Cardiomyopathy. Current Cardiology Reports [Интернет]. 2016 [цитируется по 11 апрель 2018 г.]; 18 (6). DOI: 10.1007/s11886-016-0726-9
56. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K. et al. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 2007; 131 (5): 861-72. DOI: 10.1016/j.cell. 2007.11.019
57. Miyazaki S., Yamamoto H., Miyoshi N., Takahashi H., Suzuki Y., Haraguchi N. et al. Emerging Methods for Preparing iPS Cells. Japanese Journal of Clinical Oncology. 2012; 42 (9): 773-9. DOI: 10.1093/jjco/hys108
58. Beltrami A.P., Urbanek K., Kajstura J., Yan S.-M., Finato N., Bussani R. et al. Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction. New England Journal of Medicine. 2001; 344 (23): 1750-7. DOI: 10.1056/NEJM200106073442303
59. Anversa P., Nadal-Ginard B. Myocyte renewal and ventricular remodelling. Nature. 2002; 415 (6868): 240-3. DOI: 10.1038/415240a
60. Nadal-Ginard B., Kajstura J., Leri A., Anversa P. Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ Res. 2003; 92 (2): 139-50. PMID: 12574141
61. Hsieh P.C.H., Segers V.F.M., Davis M.E., MacGillivray C., Gannon J., Molkentin J.D. et al. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nature Medicine. 2007; 13 (8): 970-4. DOI: 10.1038/nm1618
62. Bergmann O., Zdunek S., Felker A., Salehpour M., Alkass K., Bernard S. et al. Dynamics of Cell Generation and Turnover in the Human Heart. Cell. 2015; 161 (7): 1566-75. DOI: 10.1016/j.cell.2015.05.026
63. Loffredo F.S., Steinhauser M.L., Gannon J., Lee R.T. Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair. Cell Stem Cell. 2011; 8 (4): 389- 78. 98. DOI: 10.1016/j.stem.2011.02.002
64. Keith M.C.L., Bolli R. «String Theory» of c-kit (pos) Cardiac Cells: A New Paradigm Regarding the Nature of These Cells That May Reconcile Apparently Discrepant Results. Circulation Research. 2015; 116 (7): 1216-30. DOI: 10.1161/CIRCRESAHA.116.305557
65. Malliaras K., Terrovitis J. Cardiomyocyte proliferation vs progenitor cells in myocardial regeneration: The debate continues. Global Cardiology Science and Practice. 2013; 2013 (3): 37. DOI: 10.5339/gcsp.2013.37
66. Heineke J., Molkentin J.D. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nature Reviews Molecular Cell Biology. 81. 2006; 7 (8): 589-600. DOI: 10.1038/nrm1983
67. Eschenhagen T., Bolli R., Braun T., Field L.J., Fleischmann B.K., Frisén J. et al. Cardiomyocyte Regeneration: A Consensus Statement. Circulation. 2017; 136 (7): 680-6. DOI: 10.1161/CIRCULATIONAHA.82.117.029343
68. van Berlo J.H., Kanisicak O., Maillet M., Vagnozzi R.J., Karch J., Lin S.-C.J. et al. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014; 509 (7500): 337-41. DOI: 10.1038/nature13309
69. Molkentin J.D., Houser S.R. Are Resident c-kit+ Cardiac Stem Cells Really All That Are Needed to Mend a Broken Heart? Circulation Research. 2013; 113 (9): 1037-9. DOI: 10.1161/CIRCRESAHA.113.302564
70. Nadal-Ginard B., Ellison G.M., Torella D. Absence of Evidence Is Not Evidence of Absence: Pitfalls of Cre Knock-Ins in the c-Kit Locus. Circulation Research. 2014; 115 (4): 415-8. DOI: 10.1161/CIRCRESAHA.114.304676
71. Bersell K., Arab S., Haring B., Kühn B. Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury. Cell. 2009; 138 (2): 257-70. DOI: 10.1016/j.cell.2009.04.060
72. Kühn B., del Monte F., Hajjar R.J., Chang Y.-S., Lebeche D., Arab S. et al. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nature Medicine. 2007; 13 (8): 962-9. DOI: 10.1038/nm1619
73. Beltrami A.P., Barlucchi L., Torella D., Baker M., Limana F., Chimenti S. et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003; 114 (6): 763-76. PMID: 14505575
74. Messina E. Isolation and Expansion ofAdult Cardiac Stem Cells From Human and Murine Heart. Circulation Research. 2004; 95 (9): 911-21. DOI: 10.1161/01.RES. 0000147315.71699.51
75. Nadal-Ginard B., Ellison G.M., Torella D. "The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult. Stem Cell Research. 2014; 13 (3): 615-30. DOI: 10.1016/j.scr.2014.04.008
76. Ellison G.M., Vicinanza C., Smith A.J., Aquila I., Leone A., Waring C.D. et al. Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair. Cell. 2013; 154 (4): 827-42. DOI: 10.1016/j. cell. 2013.07.039
77. Vicinanza C., Aquila I., Scalise M., Cristiano F., Marino F., Cianflone E. et al. Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification. Cell Death and Differentiation. 2017; 24 (12): 2101-16. DOI: 10.1038/cdd.2017.130
78. Torella D., Ellison G.M., Karakikes I., Nadal-Ginard B. Cardiovascular development: towards biomedical applicability: Resident cardiac stem cells. Cellular and Molecular Life Sciences. 2007; 64 (6): 661-73. DOI: 10.1007/s00018-007-6519-y
79. Rasmussen T.L., Raveendran G., Zhang J., Garry D.J. Getting to the Heart of Myocardial Stem Cells and Cell Therapy. Circulation. 2011; 123 (16): 1771-9. DOI: 10.1161/CIRCULATIONAHA. 109.858019
80. Leri A., Kajstura J., Anversa P. Role of Cardiac Stem Cells in Cardiac Pathophysiology: A Paradigm Shift in Human Myocardial Biology. Circulation Research. 2011; 109 (8): 941-61. DOI: 10.1161/CIR-CRESAHA.111.243154
81. Smith A.J., Lewis F.C., Aquila I., Waring C.D., Nocera A., Agosti V. et al. Isolation and characterization of resident endogenous c-kit+ cardiac stem cells from the adult mouse and rat heart. Nature Protocols. 2014; 9 (7): 1662-81. DOI: 10.1038/nprot. 2014.113
82. Miyamoto S., Kawaguchi N., Ellison G.M., Matsuoka R., Shin»oka T., Kurosawa H. Characterization of Long-Term Cultured c-kit + Cardiac Stem Cells Derived From Adult Rat Hearts. Stem Cells and Development. 2010; 19 (1): 105-16. DOI: 10.1089/scd.2009.0041
83. Hong K.U., Guo Y., Li Q.-H., Cao P., Al-Maqtari T., Vajravelu B.N. et al. c-kit+ Cardiac Stem Cells Alleviate Post-Myocardial Infarction Left Ventricular Dysfunction Despite Poor Engraftment and Negligible Retention in the Recipient Heart. Hare JM, редактор. PLoS ONE. 2014; 9(5): e96725. DOI: 10.1371/journal.pone.0096725
84. Kawaguchi N., Smith A.J., Waring C.D., Hasan M.K., Miyamoto S., Matsuoka R. et al. c-kitpos GATA-4 High Rat Cardiac Stem Cells Foster Adult Cardiomyocyte Survival through IGF-1 Paracrine Signalling. Hotchin NA, редактор. PLoS ONE. 2010; 5 (12): e14297. DOI: 10.1371/journal.pone.0014297
85. Ellison G.M., Torella D., Dellegrottaglie S., Perez-Martinez C., Perez de Prado A., Vicinanza C. et al. Endogenous Cardiac Stem Cell Activation by Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Intracoronary Injection Fosters Survival and Regeneration of the Infarcted Pig Heart. Journal of the American College of Cardiology. 2011; 58 (9): 977-86. DOI: 10.1016/j.jacc. 2011.05.013
86. Bolli R., Chugh A.R., D»Amario D., Loughran J.H., Stoddard M.F., Ikram S. et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. The Lancet. 2011; 378 (9806): 1847-57. DOI: 10.1016/S0140-6736(11)61590-0
87. Makkar R.R., Smith R.R., Cheng K., Malliaras K., Thomson L.E., Berman D. et al. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. The Lancet. 2012; 379(9819): 895-904.
Для цитирования:
Белый С.А., Комок В.В. Клеточная терапия хронической сердечной недостаточности - современное состояние проблемы. Кардиология. 2018;58(4S):46-54. https://doi.org/10.18087/cardio.2442
For citation:
Beliy S.A., Komok V.V. Cell therapy of chronic heart failure. State of the art. Kardiologiia. 2018;58(4S):46-54. (In Russ.) https://doi.org/10.18087/cardio.2442
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