Функциональная гетерогенность фактора фон Виллебранда: патогенетическое значение и практические аспекты использования в кардиологии

Обзорная статья посвящена описанию участия фактора фон Виллебранда (ФВ), играющего важную роль в тромбообразовании при повреждении сосудов, в патогенезе сердечно-сосудистой патологии, обусловленной атеросклерозом. Избыточное образование и дисфункция ФВ, приводящие к внутрисосудистому тромбозу, способствует развитию дисфункции эндотелия, сосудистого воспаления, и, как следствие, инициации и прогрессированию атеросклероза. В обзоре представлена информация, основанная на анализе полнотекстовых публикаций в сервисе PubMed, содержащих данные о роли ФВ в развитии атеросклероза и его осложнений, а также о потенциальных возможностях влияния на этот показатель.

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