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Кардиология

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Роль липопротеида(а) в развитии атеросклеротического поражения периферических и сонных артерий

https://doi.org/10.18087/cardio.2018.6.10135

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Аннотация

Липопротеид(а) [Лп(а)] состоит из частицы, подобной липопротеиду низкой плотности (ЛНП), в которой апобелок В100 ковалентно связан с апобелком(а) с помощью одной дисульфидной связи. Лп(а) синтезируется в печени, и его концентрация в плазме крови составляет от 0 до 400 мг/дл. Повышенный уровень Лп(а) является независимым фактором риска развития сердечно-сосудистых заболеваний и ишемической болезни сердца. Данные о значении гиперлипопротеидемии (а) в развитии атеросклероза периферических артерий противоречивы. Обзор посвящен Лп(а), его связи с атеросклерозом различных сосудистых бассейнов, а также современным возможностям коррекции гиперлипопротеидемии(а).

Об авторах

Н. А. Тмоян
ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России
Россия


О. И. Афанасьева
ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России
Россия


М. В. Ежов
ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России
Россия


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Для цитирования:


Тмоян Н.А., Афанасьева О.И., Ежов М.В. Роль липопротеида(а) в развитии атеросклеротического поражения периферических и сонных артерий. Кардиология. 2018;58(6):70-78. https://doi.org/10.18087/cardio.2018.6.10135

For citation:


Tmoyan N.A., Afanasieva O.I., Ezhov M.V. The Role of Lipoprotein(a) in the Development of Peripheral and Carotid Atherosclerosis. Kardiologiia. 2018;58(6):70-78. (In Russ.) https://doi.org/10.18087/cardio.2018.6.10135

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