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Кардиология

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Роль ингибиторов неприлизина в лечении сердечной недостаточности с сохраненной фракцией выброса

https://doi.org/10.18087/cardio.2020.11.n1352

Полный текст:

Аннотация

Клиническое и гемодинамическое ухудшение при сердечной недостаточности с сохраненной фракцией выброса (СНсФВ) во многом связано с прогрессией диастолической дисфункции левого желудочка (ЛЖ). Ключевую роль в нормальном поддержании диастолической функции играет высокий уровень активности внутриклеточной сигнальной оси циклический гуанил-монофосфат–протеинкиназа G, активность которой при СНсФВ существенно снижена. Повысить активность этой оси можно путем увеличения биодоступности натрийуретических пептидов (НУП) с помощью блокады фермента нейтральной эндопептидазы (неприлизина), ответственной за разрушение НУП. В обзоре представлены имеющиеся экспериментальные и клинические данные по применению ингибиторов неприлизина при СНсФВ, рассмотрены перспективы этого способа лечения.

Об авторах

А. Г. Овчинников
ФГБУ "Национальный медицинский исследовательский центр кардиологии" Минздрава России, Москва
Россия
Доктор медицинских наук, ведущий научный сотрудник Отдела амбулаторных лечебно-диагностических технологий 


А. Д. Гвоздева
ФГБУ "Национальный медицинский исследовательский центр кардиологии" Минздрава России, Москва
Россия
Ординатор отдела легочной гипертензии и заболеваний сердца


З. Н. Бланкова
ФГБУ "Национальный медицинский исследовательский центр кардиологии" Минздрава России, Москва
Россия
Кандидат медицинских наук, научный сотрудник Отдела амбулаторных лечебно-диагностических технологий


А. А. Борисов
ФГБУ "Национальный медицинский исследовательский центр кардиологии" Минздрава России, Москва
Россия
Аспирант Отдела амбулаторных лечебно-диагностических технологий


Ф. Т. Агеев
ФГБУ "Национальный медицинский исследовательский центр кардиологии" Минздрава России, Москва
Россия
Профессор, доктор медицинских наук, главный научный сотрудник Отдела амбулаторных лечебно-диагностических технологий


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Для цитирования:


Овчинников А.Г., Гвоздева А.Д., Бланкова З.Н., Борисов А.А., Агеев Ф.Т. Роль ингибиторов неприлизина в лечении сердечной недостаточности с сохраненной фракцией выброса. Кардиология. 2020;60(11):117–127. https://doi.org/10.18087/cardio.2020.11.n1352

For citation:


Ovchinnikov A.G., Gvozdeva A.D., Blankova Z.N., Borisov A.A., Ageev F.T. The Role of Neprilysin Inhibitors in the Treatment of Heart Failure with Preserved Ejection Fraction. Kardiologiia. 2020;60(11):117–127. (In Russ.) https://doi.org/10.18087/cardio.2020.11.n1352

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