Инфекционный эндокардит неустановленной этиологии: возможности преодоления и роль микробиологистики

Современный инфекционный эндокардит (ИЭ) характеризуется изменениями этиологического и эпидемиологического профилей, ассоциированными с увеличением частоты развития ИЭ неустановленной этиологии, что диктует необходимость поиска способов повышения эффективности диагностики. Решающее значение приобретают микробиологистика, а также высокотехнологичные методы идентификации возбудителя при исследовании культуры крови и тканей пораженного клапана сердца, определяющие своевременную диагностику и лечение, внедрение которых в практическую деятельность врача является составляющей частью персонализированной медицины. В статье рассмотрены обоснованность и особенности проведения микробиологических (культуральных), иммунохимических и молекулярно-биологических [MALDI-TOF MS (матрично-активированная лазерная десорбция / ионизация с времяпролетной масс-спектрометрией), полимеразная цепная реакция, секвенирование] исследований.

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