Связь полиморфизма генов AGT, ACE, NOS3, TNF, MMP9, CYBA c субклиническими изменениями артериальной стенки

Цель    Активация ренин-ангиотензин-альдостероновой системы, снижение выработки оксида азота, хроническое воспаление и окислительный стресс приводят к субклиническим изменениям артериальной стенки, которые создают благоприятную среду для развития сердечно-сосудистых заболеваний (ССЗ). Влияние аллельных вариантов генов, кодирующих белки-участники патофизиологических путей развития возраст-ассоциированных заболеваний с субклиническими изменениями артериальной стенки [повышенной скоростью пульсовой волны (СПВ), утолщением комплекса интима-медиа, эндотелиальной дисфункцией (ЭД), наличием атеросклеротических бляшек (АСБ)] изучено недостаточно. В исследовании был проведен анализ связи полиморфизма генов AGT, ACE, NOS3 TNF, MMP9, CYBA с наличием субклинических изменений артериальной стенки, в том числе в зависимости от факторов риска ССЗ у относительно здоровых людей разного возраста.
Материал и методы    Изучена связь полиморфизма с.521С>Т гена AGT, Ins>Del гена AСE, с.894G>T гена NOS3, – 238G>A гена TNF, – 1562С>T гена MMP9, c.214Т>С гена CYBA с параметрами изменения артериальной стенки и факторами риска ССЗ у 160 относительно здоровых человек путем построения моделей множественной логистической регрессии, а также анализа частот совместного появления двух признаков с помощью критерия согласия Пирсона (χ2) и точного теста Фишера.
Результаты    Выявлена связь DD-генотипа полиморфизма Ins>Del гена ACE с повышенной СПВ (p=0,006; отношение шансов (ОШ) =3,41, 95 % доверительный интервал (ДИ): 1,48–8,67) и ЭД (p=0,014; ОШ=2,60, 95 % ДИ: 1,22–5,68). Отмечалась связь генотипа GG полиморфизма с.894G>T гена NOS3 с ЭД (p=0,0087; ОШ=2,65, 95 % ДИ: 1,26–5,72), ТТ-генотипа полиморфизма с.894G>T гена NOS3 с АСБ (p=0,033; ОШ=0,034, 95 % ДИ: 0,001–0,549).
Заключение    Выявлена взаимосвязь полиморфных вариантов генов AСE, NOS3 с ЭД, повышенной артериальной жесткостью и наличием АСБ у пациентов с субклиническими изменениями артериальной стенки.

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