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Кардиология

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Липидснижающая терапия для первичной профилактики у пациентов 75 лет и старше. Консенсус экспертов Российской ассоциации геронтологов и гериатров, Национального общества по изучению атеросклероза, Российского кардиологического общества, Ассоциации клинических фармакологов

https://doi.org/10.18087/cardio.2020.6.n1037

Полный текст:

Аннотация

Завершившиеся рандомизированные клинические исследования не обладали достаточной статистической мощностью для демонстрации отчетливой эффективности липидснижающей терапии в целях первичной профилактики у пациентов 75 лет и старше, не оценивали влияние липидснижающей терапии на развитие и течение ключевых гериатрических синдромов. Возрастные изменения скелетной мускулатуры, когнитивное снижение, старческая астения, коморбидность, полипрагмазия, потенциальные изменения фармакокинетики и фармакодинамики лекарственных средств, снижение функции почек могут неблагоприятно влиять на отношение пользы и вреда статинов у пациентов старшего возраста. Принципиальные вопросы для проведения липидснижающей терапии с целью первичной профилактики у пациентов 75 лет и старше: 1. Сохраняется ли связь между повышением уровня холестерина (ХС) липопротеидов низкой плотности (ЛНП) и смертностью; 2. Сохраняется ли польза снижения уровня ХС ЛНП; 3. Безопасна ли липидснижающая терапия; 4. Какие шкалы для стратификации риска и определения показаний к липидснижающей терапии должны использоваться?

Об авторах

Ю. В. Котовская
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава России – ОСП «Российский геронтологический научно-клинический центр», Москва
Россия

д-р мед. наук, профессор, заместитель директора по научной работе

SPIN 5698-8983



О. Н. Ткачева
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава России – ОСП «Российский геронтологический научно-клинический центр», Москва
Россия

д.м.н., профессор, директор ОСП - "Российский геронтологический научно-клинический центр"

SPIN 6129-5809



И. В. Сергиенко
ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России, Москва
Россия

главный научный сотрудник

SPIN 1643-1586



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Для цитирования:


Котовская Ю.В., Ткачева О.Н., Сергиенко И.В. Липидснижающая терапия для первичной профилактики у пациентов 75 лет и старше. Консенсус экспертов Российской ассоциации геронтологов и гериатров, Национального общества по изучению атеросклероза, Российского кардиологического общества, Ассоциации клинических фармакологов. Кардиология. 2020;60(6):119–132. https://doi.org/10.18087/cardio.2020.6.n1037

For citation:


Kotovskaya Y.V., Tkacheva O.N., Sergienko I.V. Lipid-Lowering Therapy for Primary Cardiovascular Prevention in Older Adults. Consensus Statement of the Russian Association of Gerontologists and Geriatricians, National Society on Atherosclerosis, Russian Society of Cardiology, Association of Clinical Pharmacologists. Kardiologiia. 2020;60(6):119–132. (In Russ.) https://doi.org/10.18087/cardio.2020.6.n1037

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