2016


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2016/№5

Резистентность к ацетилсалициловой кислоте: причины и следствие

Бурячковская Л. И.1, Ломакин Н. В.2, Русанова А. В.3, Вершинина М. Г.2
1 – ФГБУ «РКНПК» МЗ РФ, 121552, Москва, ул. 3‑я Черепковская, д. 15а
2 – ФГБУ «ЦКБП» УДП РФ, 121359, Москва, ул. Маршала Тимошенко, д. 15
3 – ФГБУ «УНМЦ» УД Президента РФ, 121359, Москва, ул. Маршала Тимошенко, д. 19, стр. 1а

Ключевые слова: антиагреганты, ацетилсалициловая кислота, салициловая кислота, ишемическая болезнь сердца, тромбоциты, разные формы препарата

DOI: 10.18087/rhj.2016.5.2261

Ацетилсалициловая кислота (АСК) составляет основу современной антитромбоцитарной терапии. С начала 80‑х годов XX века АСК активно вошла в клиническую практику для предупреждения развития тромботических осложнений при лечении ОКС и ИМ, ИБС, периферического атеросклероза, ТИА и ишемического инсульта, других сердечно-сосудистых состояний. Антитромботическая эффективность АСК подтверждена большим количеством исследований. Однако есть множество доказательств, что несмотря на прием препарата, он не достигает должного эффекта в снижении активности тромбоцитов и на фоне его приема могут наблюдаться тромботические события. Этот феномен получил название «резистентность» к АСК. В то же время известно, что внутривенное введение жидкой формы АСК всегда приводит к подавлению агрегации тромбоцитов и синтеза ТХА 2. В статье рассматривается влияние разных форм таблетированной АСК на этот феномен и приводятся данные о его эффективности у больных стабильной ИБС с диабетом или ХСН.
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Бурячковская Л. И., Ломакин Н. В., Русанова А. В., Вершинина М. Г. Резистентность к ацетилсалициловой кислоте: причины и следствие. Сердце: журнал для практикующих врачей. 2016;15 (5):379–388

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